The Largest Overlooked Cost Driver in Viral Vector Production
Why your nuclease strategy determines yield, quality, and cost per dose
2X
Increase in Yield
70%
Reduction in Nuclease Cost
40%
Reduction in COGS per dose
Chromatin Clearance Drives Manufacturing Economics
When chromatin is not fully digested under process-relevant conditions, recovery becomes unstable and cost per dose compounds.
Download the Full Economic Model ↓
How Costs Compound in Downstream Processing
Reduced chromatography performance
Higher enzyme consumption
Longer processing cycles
Yield loss
Optimizing nuclease strategy is one of the fastest and lowest-risk levers to improve performance without process redesigning.
In our viral vector manufacturing processes, ArcticZymes’ M-SAN HQ and SAN HQ enzymes consistently deliver efficient host-cell DNA clearance under both physiological and high-salt conditions. This has allowed us to achieve reliable digestion with fewer nuclease units, improving process efficiency without compromising quality.
Team Lead, Viral Vector Process Development at Revvity